For the full list of publications from Dr. McDowell’s labs, please click button below.
Disruption of fibronectin fibrillogenesis affects intraocular pressure (IOP) in BALB/cJ mice.
Aug 22 2020
PubMed ID: 32822410 Author(s): Faralli JA, Filla MS, McDowell CM, Peters DM. Disruption of fibronectin fibrillogenesis affects intraocular pressure (IOP) in BALB/cJ mice. PLoS One. 2020 Aug 21;15(8):e0237932. doi: 10.1371/journal.pone.0237932. eCollection 2020. PMID 32822410 Journal:…
Read MoreFibronectin extra domain A (FN-EDA) elevates intraocular pressure through Toll-like receptor 4 signaling.
Jun 20 2020
PubMed ID: 32555351 Author(s): Roberts AL, Mavlyutov TA, Perlmutter TE, Curry SM, Harris SL, Chauhan AK, McDowell CM. Fibronectin extra domain A (FN-EDA) elevates intraocular pressure through Toll-like receptor 4 signaling. Sci Rep. 2020 Jun…
Read MoreNuclear factor-kappa beta signaling is required for transforming growth factor Beta-2 induced ocular hypertension.
Jan 11 2020
PubMed ID: 31923415 Author(s): Hernandez H, Roberts AL, McDowell CM. Nuclear factor-kappa beta signaling is required for transforming growth factor Beta-2 induced ocular hypertension. Exp Eye Res. 2020 Feb;191:107920. doi: 10.1016/j.exer.2020.107920. Epub 2020 Jan 8.…
Read MoreEffects of Toll-Like Receptor 4 Inhibition on Transforming Growth Factor-β2 Signaling in the Human Trabecular Meshwork.
Dec 14 2019
PubMed ID: 31834824 Author(s): Sharma TP, Curry S, McDowell CM. Effects of Toll-Like Receptor 4 Inhibition on Transforming Growth Factor-β2 Signaling in the Human Trabecular Meshwork. J Ocul Pharmacol Ther. 2020 Apr;36(3):170-178. doi: 10.1089/jop.2019.0076. Epub…
Read MoreEffect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma.
Jun 19 2019
PubMed ID: 31211954 Author(s): Daniel S, Meyer KJ, Clark AF, Anderson MG, McDowell CM. Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma. Exp…
Read MoreSubtype-specific response of retinal ganglion cells to optic nerve crush.
Aug 01 2018
PubMed ID: 30062056 Author(s): Daniel S, Clark AF, McDowell CM. Subtype-specific response of retinal ganglion cells to optic nerve crush. Cell Death Discov. 2018 Jun 28;4:7. doi: 10.1038/s41420-018-0069-y. eCollection 2018. Erratum in: Cell Death Discov.…
Read MoreBMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork.
May 26 2018
PubMed ID: 29801150 Author(s): Hernandez H, Millar JC, Curry SM, Clark AF, McDowell CM. BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2154-2166.…
Read MoreConsensus recommendations for trabecular meshwork cell isolation, characterization and culture.
Mar 13 2018
PubMed ID: 29526795 Author(s): Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez…
Read MoreCrosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork.
Mar 28 2017
PubMed ID: 28346614 Author(s): Hernandez H, Medina-Ortiz WE, Luan T, Clark AF, McDowell CM. Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1811-1823.…
Read MoreGremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling.
Aug 19 2015
PubMed ID: 26284554 Author(s): McDowell CM, Hernandez H, Mao W, Clark AF. Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5485-92. doi: 10.1167/iovs.15-16993. Journal: Investigative Ophthalmology & Visual Science,…
Read MoreMonitoring retinal morphologic and functional changes in mice following optic nerve crush.
May 24 2014
PubMed ID: 24854856 Author(s): Liu Y, McDowell CM, Zhang Z, Tebow HE, Wordinger RJ, Clark AF. Monitoring retinal morphologic and functional changes in mice following optic nerve crush. Invest Ophthalmol Vis Sci. 2014 May 22;55(6):3766-74.…
Read MoreOptic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice.
Apr 29 2014
PubMed ID: 24767545 Author(s): Sharma TP, McDowell CM, Liu Y, Wagner AH, Thole D, Faga BP, Wordinger RJ, Braun TA, Clark AF. Optic nerve crush induces spatial and temporal gene expression patterns in retina and…
Read MoreSmad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice.
Nov 05 2013
PubMed ID: 24184030 Author(s): McDowell CM, Tebow HE, Wordinger RJ, Clark AF. Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice. Exp Eye Res. 2013 Nov;116:419-23. doi: 10.1016/j.exer.2013.10.017. Epub 2013 Oct 31.…
Read MoreMutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice.
May 12 2012
PubMed ID: 22575566 Author(s): McDowell CM, Luan T, Zhang Z, Putliwala T, Wordinger RJ, Millar JC, John SW, Pang IH, Clark AF. Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve…
Read MoreToward a Genetic Understanding of Glaucoma-Breakthroughs and Challenges from Studies of Exfoliation Glaucoma.
Apr 01 2011
PubMed ID: 26677399 Author(s): Trantow CM, Anderson MG. Toward a Genetic Understanding of Glaucoma-Breakthroughs and Challenges from Studies of Exfoliation Glaucoma. US Ophthalmic Rev. 2011 Spring;4(1):23-25. Journal: Us Ophthalmic Review, Volume 4, Issue 1, 2011
Read MoreSpectral analysis by XANES reveals that GPNMB influences the chemical composition of intact melanosomes.
Oct 30 2010
PubMed ID: 21029394 Author(s): Haraszti T, Trantow CM, Hedberg-Buenz A, Grunze M, Anderson MG. Spectral analysis by XANES reveals that GPNMB influences the chemical composition of intact melanosomes. Pigment Cell Melanoma Res. 2011 Feb;24(1):187-96. doi:…
Read MoreMicroarray analysis of iris gene expression in mice with mutations influencing pigmentation.
Aug 27 2010
PubMed ID: 20739468 Author(s): Trantow CM, Cuffy TL, Fingert JH, Kuehn MH, Anderson MG. Microarray analysis of iris gene expression in mice with mutations influencing pigmentation. Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):237-48. doi: 10.1167/iovs.10-5479.…
Read MoreElevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes.
Jul 10 2010
PubMed ID: 20617205 Author(s): Trantow CM, Hedberg-Buenz A, Iwashita S, Moore SA, Anderson MG. Elevated oxidative membrane damage associated with genetic modifiers of Lyst-mutant phenotypes. PLoS Genet. 2010 Jul 1;6(7):e1001008. doi: 10.1371/journal.pgen.1001008. Journal: P Lo…
Read MoreLyst mutation in mice recapitulates iris defects of human exfoliation syndrome.
Nov 26 2008
PubMed ID: 19029039 Author(s): Trantow CM, Mao M, Petersen GE, Alward EM, Alward WL, Fingert JH, Anderson MG. Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1205-14.…
Read MoreIris phenotypes and pigment dispersion caused by genes influencing pigmentation.
Aug 22 2008
PubMed ID: 18715234 Author(s): Anderson MG, Hawes NL, Trantow CM, Chang B, John SW. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res. 2008 Oct;21(5):565-78. doi: 10.1111/j.1755-148X.2008.00482.x. Epub 2007 Jun…
Read MoreGpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma.
Apr 12 2008
PubMed ID: 18402690 Author(s): Anderson MG, Nair KS, Amonoo LA, Mehalow A, Trantow CM, Masli S, John SW. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet. 2008…
Read MoreMotility of a biflagellate sperm: waveform analysis and cyclic nucleotide activation.
Sep 14 2004
PubMed ID: 15362116 Author(s): Howard DR, Trantow CM, Thaler CD. Motility of a biflagellate sperm: waveform analysis and cyclic nucleotide activation. Cell Motil Cytoskeleton. 2004 Oct;59(2):120-30. Journal: Cell Motility And The Cytoskeleton, Volume 59, Issue…
Read More