Identification of new mouse models of glaucoma
Several different types of mouse models of glaucoma have been developed such as spontaneous genetic models, transgenic models, as well as various inducible models to elevate IOP including physically damaging the outflow pathway, occluding the TM, treating with glucocorticoids, or using viral vectors encoding glaucoma associated transgenes to transduce the TM. Although there are many advantages to each of these models, there is still not an ideal model of glaucoma as many either do not mimic all aspects of human glaucoma, have variable phenotypes between animals, or are labor intensive and involve extensive breeding and aging of the animals. My laboratory aims to identify a mouse model of glaucoma that mimics human glaucoma, is homogenous in response, and provides phenotypes without extensive breeding/aging. We have a candidate model in the laboratory now that we are actively characterizing for elevated IOP, RGC damage, and damage to the optic nerve and optic nerve head.