PubMed ID: 42461077 Author(s): Mavlyutov TA, Bilal SE, Sharmin T, McDowell CM. Novel Role for CGRP in Aqueous Humor Outflow. Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):39. doi: 10.1167/iovs.67.8.39. PMID 42461077 Journal: Investigative Ophthalmology & Visual Science, Volume 67, Issue 8, Jul 2026 PURPOSE Calcitonin gene related peptide (CGRP)-positive nerve fibers are the major type …
PubMed ID: 41631754 Author(s): Broekema NM, Larsen IV, Griese C, Naruzawa ES, Himmerich S, Stern NW, Chesmore N, Kolb AW, McDowell CM, Brandt CR. The Use of Free-Living Amoeba in Treating Bacterial Infections: Thermotolerant Dictyostelids Are Avirulent and Do Not Cause Keratitis in Mice. Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):7. doi: 10.1167/iovs.67.2.7. PMID 41631754 …
PubMed ID: 42564195 Author(s): Sharmin T, McDowell CM. Integrin alpha4 and alpha9 in trabecular meshwork and Schlemm’s canal function: emerging regulators of intraocular pressure homeostasis. Front Cell Dev Biol. 2026 Jul 23;14:1862957. doi: 10.3389/fcell.2026.1862957. eCollection 2026. PMID 42564195 Journal: Frontiers In Cell And Developmental Biology, Volume 14, 2026 Integrins are hetero-dimeric transmembrane receptors that facilitate …
PubMed ID: 40216065 Author(s): Mavlyutov T, Bilal SE, Myrah JJ, Mathers KM, Lee TY, McDowell CM. TGFbeta2 alters segmental outflow and ECM ultrastructure in the trabecular meshwork. Exp Eye Res. 2025 Apr 10;255:110377. doi: 10.1016/j.exer.2025.110377. Online ahead of print. PMID 40216065 Journal: Experimental Eye Research, Volume 255, Apr 2025 TGFβ2 is a well-known contributor to …
PubMed ID: 39894294 Author(s): McDowell CM, Dutca LM, Thompson S, Riker M, Hedberg-Buenz A, Meyer KJ, Anderson MG. Disruption of circadian intraocular pressure fluctuations in mice by the Lyst beige-J mutation. Exp Eye Res. 2025 Mar;252:110266. doi: 10.1016/j.exer.2025.110266. Epub 2025 Jan 31. PMID 39894294 Journal: Experimental Eye Research, Volume 252, Mar 2025 Intraocular pressure (IOP) …
PubMed ID: 39433672 Author(s): McDowell CM. The Inducible TGFbeta2 Ocular Hypertension Mouse Model. Methods Mol Biol. 2025;2858:123-129. doi: 10.1007/978-1-0716-4140-8_11. PMID 39433672 Journal: Methods In Molecular Biology (Clifton, N.J.), Volume 2858, 2025 There is a great need for the development of mouse models of ocular hypertension. Here, we describe an inducible mouse model of ocular hypertension …
PubMed ID: 39693082 Author(s): Acott TS, Fautsch MP, Mao W, Ethier CR, Huang AS, Kelley MJ, Aga M, Bhattacharya SK, Borras T, Bovenkamp D, Chowdhury UR, Clark AF, Dibas MI, Du Y, Elliott MH, Faralli JA, Gong H, Herberg S, Johnstone MA, Kaufman PL, Keller KE, Kelly RA, Krizaj D, Kuehn MH, Li HL, Lieberman …
PubMed ID: 39382882 Author(s): Geiduschek EK, Bricco EK, McDowell CM. DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH. Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):13. doi: 10.1167/iovs.65.12.13. PMID 39382882 Journal: Investigative Ophthalmology & Visual Science, Volume 65, Issue 12, Oct 2024 PURPOSE The optic nerve head (ONH) is well known to be the initial site …
PubMed ID: 37686046 Author(s): Geiduschek EK, McDowell CM. The Fibro-Inflammatory Response in the Glaucomatous Optic Nerve Head. Int J Mol Sci. 2023 Aug 26;24(17):13240. doi: 10.3390/ijms241713240. PMID 37686046 Journal: International Journal Of Molecular Sciences, Volume 24, Issue 17, Aug 2023 Glaucoma is a progressive disease and the leading cause of irreversible blindness. The limited therapeutics …
PubMed ID: 36152913 Author(s): Mavlyutov TA, Kuhn MS, Bilal SE, De Ieso ML, Chauhan AK, Stamer WD, McDowell CM. Decreased outflow facility and Schlemm’s canal defects in a mouse model of glaucoma. Exp Eye Res. 2022 Dec;225:109249. doi: 10.1016/j.exer.2022.109249. Epub 2022 Sep 21. PMID 36152913 Journal: Experimental Eye Research, Volume 225, Dec 2022 Previously we …